Cika keɓaɓɓen rufi a ainihin amfani ya kamata ya yi oda daban-daban kayayyaki bisa ga daban-daban samar da muhalli bukatun; Dangane da sabon sigar GMP (2010 edition) bayyananne bukatun, (babban haɗari aiki yankin, ciki har da cikawa don ruwa allura, freeze bushewa allura da kuma babban infusion cikawa, da kuma rufi, nauyi, samfurin dole ne a bukatar a yi a cikin dangantaka keɓewa yanayi; a karkashin wannan babban bango, m mafi yawan magunguna kamfanonin da suka yi amfani da halin yanzu dangantaka farashin ƙananan yanke da sassauƙa shigar da wasu aiki ORABS keɓewa shinge tsarin.